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Health Science and Exercise Leadership (DHSc)
Association of Lean Body Mass to Menopausal Symptoms in the Study of Women's Health Across the Nation
Association of Lean Body Mass to Menopausal Symptoms in the Study of Women's Health Across the Nation
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Details
Title
Association of Lean Body Mass to Menopausal Symptoms in the Study of Women's Health Across the Nation: a Dissertation
Creator
Subject
Menopause
Description
Vasomotor symptoms (VMS) are experienced by most women as they transition through menopause, but their etiology is incompletely understood as is their relationship to body composition. While the association of VMS to body fat, body weight, and body mass index has been broadly researched, little is known about the role of lean body mass. The purpose of this research was to examine the association of lean body mass (LBM) to the development of VMS as women transition through menopause. Data from 2,533 participants in the longitudinal Study of Women’s Health Across the Nation (SWAN) who provided bioelectrical impedance (BIA) measurements over five visits, was accessed and examined. Women who reported no VMS at baseline were modelled for concurrent association of skeletal muscle mass and fat free mass with VMS, and additionally for percent change since prior visit and percent change since baseline. Adjusted models included covariates of fat mass, age, race/ethnicity, education, and menopausal status. VMS with concurrent LBM was significant in unadjusted (p <.0001) and adjusted models (p = .036). Percent change since prior visit and since baseline models were significant (adjusted p = .003, p <.001; unadjusted p = .009, p = .001) and overall mean association remained significant (p = .007, p = .023). Associations at each visit were not significant in logistic regression. Predicted probabilities of VMS showed a negative correlation to lean body mass for all visits and overall regression analysis. These results suggest that maintaining higher levels of LBM as women progress through menopause may protect against the development of VMS.
Publisher
Contributor
Woods, Rosanne (Author)
Date
2018-12-14
Type
Text
Format
Identifier
cali:26
Source
Language
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